Technology

Integration of advanced technologies based on skin research

Taking skin research to the next level to control aging.
We have been working on research to make this wish come true and have focused on dermal stem cells, which hold the key to skin's youth.

Hi, I'm Chika Katagiri. Here, I would like to explain our longtime research on skin physiology, electrical stimulation using skin tissue, and ingredients.

[Profile]

Shiseido Co.,Ltd.
MIRAI Technology Institute Executive Scientist
Chika Katagiri

[Profile]

Shiseido Co.,Ltd.
MIRAI Technology Institute Executive Scientist
Chika Katagiri

Dermal Stem Cells:
The Key to Beautiful Skin

To maintain youthful skin, it is important that the collagen, elastin, and hyaluronic acid in the dermis, which are the three main elements that create a youthful impression, are all in a healthy state.
Dermal stem cells are responsible for producing the fibroblasts that produce these elements. In other words, dermal stem cells are the mother cells that give birth to new skin tissue.

Dermal stem cells hold the key to skin's youthfulness, but they decrease with age.

New findings

Found that specific electrical stimulation (ST-R) increases the number of stem cells!

After years of research, we discovered that specific electrical stimulation (ST-R) works on capillaries and increases the number of dermal stem cells.

Specific electrical stimulation (ST-R) not irradiated
Specific electrical stimulation (ST-R) irradiated

^*Arrowed area: dermal stem cells
^*Red: ITGA6 Green: MCSP (dermal stem cell marker)

Specific electrical stimulation (ST-R) not irradiated
- ^*Arrowed area: dermal stem cells
- ^*Red: ITGA6 Green: MCSP (dermal stem cell marker)
Specific electrical stimulation (ST-R) irradiated
- ^*Arrowed area: dermal stem cells
- ^*Red: ITGA6 Green: MCSP (dermal stem cell marker)

New findings

The ability to produce all three major elements of youthful skin^* is significantly increased!

^*Collagen, elastin, and hyaluronic acid, which support the elasticity and resilience of the dermis

As a result of further research, we discovered that the ability of fibroblasts born from dermal stem cells to produce three major elements of the dermis, collagen, elastin, and hyaluronic acid, is enhanced by specific electrical stimulation (ST-R) and the action of specific ingredients.

As you can see, the results were astonishing.

Lifting up of the skin by electrical stimulation

As a result of measuring which direction the skin was lifted in after intensive irradiation with specific electrical stimulation (ST-R) under certain conditions, it was found that the skin tightened upward, mainly in the cheek area.^*

The lifting result is indicated with the color (blue: 0.5mm~yellow~red: 2.5mm) and the direction of the arrows.
After the base formula containing the ingresients was applied, a specific electrical stimulation was applied for 4 minutes for seven days, twice a day.

Behind the research

Delivering benefits and safety to the skin

We have repeatedly researched cosmetic ingredients and the electrical stimulation effects of beauty devices on the skin, and confirmed their effectiveness and safety through long-term continuous use tests on human skin.
From Japan to the world, the challenge of new beauty values

The cornerstone of our technology is the relentless pursuit by our researchers to create new beauty experiences that have never been seen and to achieve things that no one has ever thought of before. Our goal is to deliver new value to consumers for the first time not only in Japan but also the world.
Our ideas originate from the collaboration of knowledge

The coming together of members' individual personalities with different backgrounds creates new solutions beyond the realm of each discipline. In addition, innovations are sometimes born from casual conversations. Sharing information and exchanging ideas among researchers lead to new ideas and solutions never seen before.
A group of experts in advanced scientific research

As experts in various research fields, such as skin research, material science, electronics, and electrical engineering, we continue to make new discoveries by challenging ourselves with various skin research and experiments. This is where the wisdom of these advanced sciences is gathered.